含水量不同時(overhydrated & dehydrated)，甫流入collecting duct 之腎小管內液之osmolality 各為100&300mOsm，而血漿的osmolality 為275-295mOsm
AQP1 : apical and basolateral membranes of the proximal tubule and descending thin limb of Henle's loop.
**AQP2** : apical plasma membrane of principal cells in the collecting duct, and its expression in the membrane is regulated by antidiuretic hormone (ADH).
AQP3 and AQP4 : basolateral membrane of principal cells in the collecting duct.
Mice deficient in AQP3 or AQP4 (i.e., knockout mice) have defected ability to concentrate urine.
所以可知Collecting duct 上出現的是AQP2, AQP3, AQP4
而 AQP2 又會受到 ADH 的 調控
腎小管可回收" 濾液 "中的水分含量達99%．非全身水分
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